A groundbreaking study from Baycrest has revealed that elevated blood sugar levels may impair brain health—even in individuals without diabetes. While the link between blood sugar and cognitive decline has long been established in those diagnosed with diabetes, this new research is the first to show that even moderately elevated glucose levels can negatively impact brain function in otherwise healthy adults. “Blood sugar exists on a spectrum,” says Dr. Jean Chen, Senior Scientist at the Rotman Research Institute. “Our results suggest that even without a diagnosis, higher glucose levels may already be taking a toll on the brain.”
Published in the journal Neurobiology of Aging, the study analyzed 146 healthy adults using MRI scans to assess brain activity, ECG readings for heart rate variability, and blood sugar levels. Researchers found that higher glucose was associated with weakened connectivity in essential brain networks responsible for memory, attention, and emotional regulation. These effects were more pronounced in older adults and in women, though present across all age groups. In addition, elevated blood sugar correlated with lower heart rate variability—another sign of declining neurological resilience.
This landmark research underscores the critical importance of proactive blood sugar management not just for physical health, but for preserving cognitive function. It also stands as a shining example of what Baycrest can achieve with the help of its generous community. Breakthroughs like this are made possible in large part due to continued philanthropic support—and initiatives like the Mattamy Homes Bike for Brain Health play a vital role in funding this life-changing research.
By participating in or donating to the Mattamy Homes Bike for Brain Health on June 1, 2025, you’re directly supporting Baycrest’s mission to defeat age-related cognitive decline and build a future where everyone can age with dignity and vitality. This study is just one of many remarkable accomplishments made possible by the dedication of researchers and the unwavering commitment of our donors and community. Join us on this journey—because every dollar raised fuels discovery, hope, and better brain health for generations to come.